Curriculum Vitæ

I’m currently working for the Institut Pasteur de Lille at the UMR 8199 - “Integrated Genomics and Metabolic Diseases Modelling” as the head of the biostatistic team.

Doctor of Philosophy (Ph.D.) in BioStatistics

University of Lille

Lille, France

Oct. 2014 - Sep. 2017

Thesis: Development and Application of Statistical Methods for Multi-Omics Studies in Type 2 Diabetes: Beyond the Genome-Wide Association Studies Era

Master’s Degree in Biostatistics, Bioinformatics and Genomics (Specialised in Biostatistics)

University Claude Bernard Lyon 1

Lyon, France

Sep. 2009 - Jul. 2011

Internships:

• Mathematical Modelling of Nosocomial Rotavirus Infections in Pediatric Ward
• Development of a Non-Parametric (on Time) Clustering Algorithm for Longitudinal Data

Bachelor’s Degree in Biology (Specialised in Biostatistics)

University Claude Bernard Lyon 1

Lyon, France

Sep. 2006 - Jul. 2009

Head of the Biostatistic Team

Laboratory of Integrated Genomics
and Metabolic Diseases Modeling
EGID - UMR 8199
(European Genomics Institute for Diabetes)

Lille, France

Jan. 2016 - Present

Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments, team management

Biostatistician

Laboratory of Integrated Genomics
and Metabolic Diseases Modeling
EGID - UMR 8199
(European Genomics Institute for Diabetes)

Lille, France

Sep. 2012 - Dec. 2015

Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments

Biostatistician

French Institute of Science and Technology for
Transport, Development and Networks (IFSTTAR)
UMRESTTE - UMR T9405

Bron, France

Nov. 2011 - Dec. 2011

Activities: Analysis of a mobility and accident study in secondary-school pupils

Biostatistician (Internship)

Hospices Civiles de Lyon
Biostatistics Unit
UMR CNRS 5558

Lyon, France

Jan. 2011 - Jun. 2011

Activities: Development of a Non-Parametric (on Time) Clustering Algorithm for Longitudinal Data

Biostatistician (Internship)

Biometry and Evolutionary Biology laboratory
(LBBE)
UMR CNRS 5558

Lyon, France

Mar. 2010 - Jun. 2010

Activities: Mathematical Modelling of Nosocomial Rotavirus Infections in Pediatric Ward

R and Databases

Two-days training (in French)
“Unités Régionales de Formation
à l’Information Scientifique et Technique”
(URFIST)

Bordeaux, France

2018

Julia for Intensive Scientific Computing

Half-day workshop (in French)
“Journées nationales du
DEVeloppement logiciel”
(JDEV)

Bordeaux, France

2015

CARoT: Centralised and Automated RepOrting Tools

Mickaël Canouil, Mathilde Boissel and Lijiao Ning

N/A

Apr. 2019

https://github.com/mcanouil/CARoT/

NACHO: NanoString Quality Control Dashboard

Mickaël Canouil, Gerard Bouland and Roderick Slieker

N/A

Apr. 2019

https://cran.r-project.org/package=NACHO

clere: Simultaneous Variables Clustering and Regression

Loïc Yengo, Julien Jacques, Christophe Biernacki and Mickaël Canouil

N/A

Feb. 2014

https://cran.r-project.org/package=clere

snpEnrichment: SNPs Enrichment Analysis

Mickaël Canouil and Loïc Yengo

N/A

Apr. 2013

https://cran.r-project.org/package=snpEnrichment

Funding Allocation SFD-Lilly

"Société Francophone du Diabète
(SFD)

Bordeaux, France

2015

Project: Detection of new genomic variants associated with fasting blood glucose and incidence of type 2 diabetes simultaneously

Jointly Modelling SNPs with Survival & Longitudinal Trait

Thematic Day “Statistic & Genomic”
of the Réseau Interdisciplinaire
autour de la Statistique
(RIS)

Paris, France

2018

Longitudinal Genetic Modelling: Revisiting Associations of SNPs Associated with Blood Fasting Glucose in Normoglycemic Individuals

Statistical Methods for Post Genomic Data
(SMPGD)

Lille, France

2016

“Variants Génétiques Associés à la Trajectoire de la Glycémie à Jeun et à l’Incidence du Diabète de Type 2: Une Approche par Modèle Joint” (CA-075)

Annual Congress
of
“Société Francophone du Diabète”
(SFD)

Lille, France

2017

Single Nucleotide Polymorphisms Associated With Fasting Blood Glucose Trajectory And Type 2 Diabetes Incidence: A Joint Modelling Approach

4th Symposium
European Genomic Institute for Diabetes
(EGID)

Lille, France

2016

Single Nucleotide Polymorphisms Associated With Fasting Blood Glucose Trajectory And Type 2 Diabetes Incidence: A Joint Modelling Approach

International Genetic Epidemiology Society
(IGES)

Toronto, Canada

2016

Application of Joint Models in Genetic Association Studies

International Genetic Epidemiology Society
(IGES)

Baltimore, United-States

2015

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Amy R. Bentley, Yun J. Sung, Michael R. Brown, Thomas W. Winkler, Aldi T. Kraja, Ioanna Ntalla, Karen Schwander, Daniel I. Chasman, Elise Lim, …, Mickaël Canouil⁹⁷ et al.

N/A

Apr. 2019

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Yun Ju Sung, Lisa de las Fuentes, Thomas W. Winkler, Daniel I. Chasman, Amy R. Bentley, Aldi T. Kraja, Ioanna Ntalla, Helen R. Warren, Xiuqing Guo, …, Mickaël Canouil⁹⁵ et al.

N/A

Apr. 2019

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Amna Khamis, Mickaël Canouil^†, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter et al.

N/A

Mar. 2019

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Lifelines Cohort Study Lifelines Cohort Study, Tuomas O. Kilpeläinen, Amy R. Bentley, Raymond Noordam, Yun Ju Sung, Karen Schwander, Thomas W. Winkler, Hermina Jakupović, Daniel I. Chasman, …, Mickaël Canouil⁷⁵ et al.

N/A

Jan. 2019

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Paul S. de Vries, Michael R. Brown, Amy R. Bentley, Yun J. Sung, Thomas W. Winkler, Ioanna Ntalla, Karen Schwander, Aldi T. Kraja, Xiuqing Guo, …, Mickaël Canouil⁸¹ et al.

N/A

Jan. 2019

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason M. Torres, N. William Rayner, Anthony J. Payne, Valgerdur Steinthorsdottir, Robert A. Scott, …, Mickaël Canouil³⁵ et al.

N/A

Oct. 2018

Type 2 diabetes–associated variants of the MT2 melatonin receptor affect distinct modes of signaling

Angeliki Karamitri, Bianca Plouffe, Amélie Bonnefond, Min Chen, Jonathan Gallion, Jean-Luc Guillaume, Alan Hegron, Mathilde Boissel, Mickaël Canouil, Claudia Langenberg et al.

N/A

Aug. 2018

Jointly Modelling Single Nucleotide Polymorphisms With Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose

Mickaël Canouil^†, Beverley Balkau, Ronan Roussel, Philippe Froguel and Ghislain Rocheleau

N/A

Jun. 2018

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, Ioanna Ntalla, Xiuqing Guo, Nora Franceschini, Ching-Yu Cheng, …, Mickaël Canouil⁸⁷ et al.

N/A

Jun. 2018

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes

Amar Abderrahmani, Loïc Yengo, Robert Caiazzo, Mickaël Canouil^†, Stéphane Cauchi, Violeta Raverdy, Valérie Plaisance, Valérie Pawlowski, Stéphane Lobbens, Julie Maillet et al.

N/A

May 2018

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

Anubha Mahajan, Jennifer Wessel, Sara M. Willems, Wei Zhao, Neil R. Robertson, Audrey Y. Chu, Wei Gan, Hidetoshi Kitajima, Daniel Taliun, …, Mickaël Canouil⁶⁸ et al.

N/A

Apr. 2018

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Yun J. Sung, Thomas W. Winkler, Lisa de Las Fuentes, Amy R. Bentley, Michael R. Brown, Aldi T. Kraja, Karen Schwander, Ioanna Ntalla, Xiuqing Guo, …, Mickaël Canouil⁹⁴ et al.

N/A

Mar. 2018

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

Fatou K. Ndiaye, Ana Ortalli, Mickaël Canouil^†, Marlène Huyvaert, Clara Salazar-Cardozo, Cécile Lecoeur, Marie Verbanck, Valérie Pawlowski, Raphaël Boutry, Emmanuelle Durand et al.

N/A

Jun. 2017

Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles

Marie Verbanck, Mickaël Canouil^†, Audrey Leloire, Véronique Dhennin, Xavier Coumoul, Loïc Yengo, Philippe Froguel and Odile Poulain-Godefroy

N/A

Jun. 2017

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

Gaelle R. Carrat, Ming Hu, Marie-Sophie Nguyen-Tu, Pauline Chabosseau, Kyle J. Gaulton, Martijn van de Bunt, Afshan Siddiq, Mario Falchi, Matthias Thurner, Mickaël Canouil et al.

N/A

Feb. 2017

Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach

Amélie Bonnefond, Loïc Yengo, Aurélie Dechaume, Mickaël Canouil, Maxime Castelain, Estelle Roger, Frédéric Allegaert, Robert Caiazzo, Violeta Raverdy, Marie Pigeyre et al.

N/A

Feb. 2017

Hepatic DPP4 DNA Methylation Associates With Fatty Liver

Christian Baumeier, Sophie Saussenthaler, Anne Kammel, Markus Jähnert, Luisa Schlüter, Deike Hesse, Mickaël Canouil, Stephane Lobbens, Robert Caiazzo, Violeta Raverdy et al.

N/A

Jan. 2017

Variable Clustering in High-Dimensional Linear Regression: The R Package clere

Loïc Yengo, Julien Jacques, Christophe Biernacki and Mickaël Canouil

N/A

Apr. 2016